About the Director
||Dr Denis Richard, Ph. D.
Director of research
Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)
2725, chemin Sainte-Foy
Québec, QC Canada G1V 4G5
Tél.: 418-656-8711 ext. 3392
Fax : 418-656-4929
E-mail : Denis.Richard@criucpq.ulaval.ca
Full Professor, Faculty of Medicine, Department of Medicine
Director of research, Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ)
Director, Université Laval's Interdisciplinary Research Group on Obesiry (GIROUL)
Chair, Université Laval's Research Chair on Obesity
- American Physiological Society
- Association de Physiologistes (International- French Speaking nations)
- Endocrine Society
- International Society for Autonomic Neuroscience
- NAASO. The Obesity Society
- Canadian Physioogica Society
- Society for Neuroscience
- Society for the Study of Ingestive Behavior
- Post doctoral studies in Nutrition & Physiology, Dunn Nutrition Unit, Cambridge University (Cambridge, UK), 1982-1984.
- Master's degree and Doctorate (Ph.D.) in Physiology, Université Laval, 1978-1982.
|Energy Balance Regulation
Variations in energy stores or energy balance reflect the difference between energy intake and energy expenditure and are generally associated with changes in body weight and, variations in fat mass. Given the high degree of fat mass stability throughout adult life, despite the tremendous amount of energy flowing through the organism, it can be argued that the level of energy stores is regulated. Brain circuitries involved in the control of energy intake (food intake) and energy expenditure (thermogenesis) seem capable of integrating peripheral signals, produced by perturbations of adipose tissue mass, into messages to effectors of food intake and energy expenditure, so as to prevent substantial variations in the level of energy reserves.
D. Richard studies the regulation of energy balance. Related to his research program are the following general and specific objectives:
- To study of the neurosystems involved in the control of food intake and thermogenesis
- Determination of the mechanisms governing the action of the corticotropin-releasing hormone (CRH), neuropeptide Y (NPY), melanin-concentrating hormone (MCH), thyrotropin-releasing hormone (TRH), serotonin (5-hydroxytryptamine, 5-HT), and proopiomelanocortin (POMC) in the control of food intake and thermogenesis.
- Determination of the neuronal circuits involved in the regulation of energy balance through the identification of sites of synthesis (neuronal bodies) and action (receptors) of the above mentioned neuromolecules.
- Identification and determination of the role of new neuromolecules in the regulation of energy balance.
- To study of the periphery-central nervous system interrelationships in the regulation of energy balance
- Determination of the sites and mechanisms of action of leptin, corticosteroids (corticosterone, cortisol, aldosterone), and insulin in the control of food intake and energy expenditure.
- To study of the effectors of food intake and thermogenesis
- Determination of the effectors of food intake and description of the circuitries coupling the regulatory centres with effectors of thermogenesis via the sympathetic nervous system.
- Role of the uncoupling proteins (UCP1, 2, 3) in the regulation of energy balance.
This research is funded by the Canadian Institutes for Health Research (CIHR) – INMD, the Canada Foundation for Innovation (CFI), the Natural Sciences and Engineering Research Council (NSERC), the Fondation de l’Université Laval and the Fonds de la recherche en santé du Québec (FRSQ).