Research Chair on Obesity Centre de recherche Institut Universitaire de Cardiologie et de Pneumologie du QuébecUniversité Laval
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Research Program

Obesity is developing into an epidemic and now constitutes a significant financial burden to healthcare systems. Despite recent years’ advancements, the complex etiology of obesity remains misunderstood largely because the hormonal and neuronal mechanisms of the regulation of food intake and energy expenditure engaged in body weight regulation have not yet been clearly established. The Chair’s research program aims to establish the mechanisms that regulate energy balance. Specifically, the program’s key objective is to identify the central neuronal circuitries and the peripheral metabolic pathways engaged in the regulation of energy balance, around which six research subprograms were developed. These subprograms will be carried out with the help of a multidisciplinary group of collaborators.

Subprogram 1: The role of UCP2 in the homeostatic regulation of energy balance

Objective: To determine the metabolic role of this uncoupling protein which is highly expressed in hypothalamic regions engaged in energy metabolism.

Subprogram 2: Vagus nerve signalling and the regulation of energy balance

Objective: To study the role of vagal afferents in the regulation of energy balance. Vagal afferents express many receptors and molecules engaged in the regulation of energy balance.

Subprogram 3: Role of PPAR in the regulation of energy balance

Objective: To determine the mechanisms by which PPAR receptors affect the regulation of energy balance in the central nervous system.

Subprogram 4: The endocannabinoids and the regulation of energy balance

Objective: To determine the mechanisms by which endocannabinoids affect food intake and energy expenditure.

Subprogram 5: Role of MCH in the regulation of energy balance

Objective: To determine the mechanisms by which the MCH system affects food intake and energy expenditure, with emphasis on the role of the MCH system in the development of antipsychotic drug-induced obesity.

Subprogram 6: Stress and obesity: Involvement of Neuronal Circuitries

Objective: To identify and study neuronal circuitries engaged in the stress reactions to fasting in various models of obesity.

Research Funding (Université Laval VRR)




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